Highly Stable Core-Surface-Crosslinked Micelles as Drug Carriers for Cancer Chemotherapy
نویسندگان
چکیده
Stealth nanoparticles made of polymer micelles are ideal drug carriers for targeted drug delivery, but their stability is critical for intravenous applications. We found that core-surfacecrosslinked nanoparticles (SCNp) made from amphiphilic brush copolymers had greatly enhanced stability. The surface of the SCNps can be easily tailored by using different chains. The amphiphilic brush copolymers consisted of hydrophobic poly(caprolactone) (PCL) and hydrophilic poly(ethylene glycol) (PEG) or poly(2-(dimethylaminoethyl methacrylate) (PDMA) chains were used to fabricate SCNps. Positively charged PCL/PDMA SCNps could be internalized more efficiently by ovarian cancer cells, leading to an enhanced anticancer drug efficacy.
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